<div data-page-id="doxcnOjeQeMkGHV8ft82bMxBdAg" data-docx-has-block-data="true"> <div class="image-uploaded gallery old-record-id-doxcneqkmgiIkugiYMhGTjEY8Mf" data-type="image" data-ace-gallery-json="{&quot;items&quot;:[{&quot;uuid&quot;:&quot;c57b37c1-ec94-44d0-b594-c0813a39a7a2&quot;,&quot;height&quot;:257,&quot;width&quot;:420,&quot;currHeight&quot;:257,&quot;currWidth&quot;:420,&quot;natrualHeight&quot;:257,&quot;natrualWidth&quot;:420,&quot;pluginName&quot;:&quot;imageUpload&quot;,&quot;scale&quot;:1,&quot;src&quot;:&quot;https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2FboxcnDzdL45yh1hcFQcebdTWHAh%2F%3Fmount_node_token%3DdoxcneqkmgiIkugiYMhGTjEY8Mf%26mount_point%3Ddocx_image&quot;,&quot;file_token&quot;:&quot;boxcnDzdL45yh1hcFQcebdTWHAh&quot;,&quot;image_type&quot;:&quot;image/jpeg&quot;,&quot;size&quot;:14879,&quot;comments&quot;:[]}]}"><span class="p"><img style="display: block; margin-left: auto; margin-right: auto;" 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style="text-align: justify;"><span class="p">根據(jù)昆士蘭大學對小鼠的一項研究，無針疫苗貼片可以比傳統(tǒng)的針頭疫苗更好地對抗COVID-19變體，如Omicron和Delta。</span></div> <div class="ace-line ace-line old-record-id-doxcnYgCmUsYa2QAwQ78TdOsUlb" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn0MG2mqyAIyICKYek9CqBTg" style="text-align: justify;"><span class="p">該研究與布里斯班生物技術公司Vaxxas合作進行，使用Vaxxas高密度微陣列貼片（HD-MAP）技術測試了Hexapro SARS-CoV-2刺殺疫苗，結果發(fā)現(xiàn)該貼片在中和COVID-19變體方面要有效得多。</span></div> <div class="ace-line ace-line old-record-id-doxcny6wQWwauQyEUwZcsDwsz5t" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn4Mgsgk808CisKypJjKqcrf" style="text-align: justify;"><span class="p">昆士蘭大學的Christopher McMillan博士說，疫苗貼片似乎比目前通過注射提供的SAR-CoV-2疫苗更有效地抵消了新變種。</span></div> <div class="ace-line ace-line old-record-id-doxcnoAO8icEyKSSSo9z6xKgpEb" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcna4C88OQCQgaAALGQNOOIFh" style="text-align: justify;"><span class="p">&ldquo;高密度微陣列貼片是一種疫苗遞送平臺，可將疫苗精確地輸送到富含免疫細胞的皮膚層中，&rdquo;McMillan博士說。</span></div> <div class="ace-line ace-line old-record-id-doxcnGaCMWCo284gqsF99dwonmg" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIoasgAMAWYKe0MMMtuFoYg" style="text-align: justify;"><span class="p">&ldquo;我們發(fā)現(xiàn)，與通過針頭施用的相同疫苗相比，通過貼片接種疫苗在對抗Omicron變體方面的效果大約高出11倍。</span></div> <div class="ace-line ace-line old-record-id-doxcnwGq4WoO4YqoGaOq2dH5xhe" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnE6uiCcCgSMgMGA3FwMuXXd" style="text-align: justify;"><span class="p">他說，結果比Hexapro疫苗更進一步。</span></div> <div class="ace-line ace-line old-record-id-doxcnQYyAGQ6WYY0i0E0RBRXo7f" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnyKeoyayKmUgs4MHpjPpl8e" style="text-align: justify;"><span class="p">&ldquo;到目前為止，我們通過貼片測試的每種疫苗類型，包括亞基，DNA，滅活病毒和偶聯(lián)物，與傳統(tǒng)的針頭疫苗接種方法相比，都能產生卓越的免疫反應，&rdquo;他說。</span></div> <div class="ace-line ace-line old-record-id-doxcne806AWECyOscwPTl48VyVe" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn2MwaOeceUcA6QXcCPgzzdh" style="text-align: justify;"><span class="p">昆士蘭大學教授David Muller博士表示，由于COVID-19的新變種不斷涌現(xiàn)，目前可用的疫苗可能不那么有效，這讓研究人員處于十字路口。</span></div> <div class="ace-line ace-line old-record-id-doxcnq6KmeaKEI0IMqghESMXJbf" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn8E84kCMI2wuecL2KlJ52Eg" style="text-align: justify;"><span class="p">&ldquo;這種降低的有效性在Omicron變體中得到了突出，該變體在刺突蛋白中含有30多個突變，&rdquo;Muller博士說。</span></div> <div class="ace-line ace-line old-record-id-doxcnEOcEkgyICkyweetOkMcwQc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn2Iaw0cAGsAQ2WKsA0Lyz9f" style="text-align: justify;"><span class="p">&ldquo;大量的突變使病毒能夠逃避當前疫苗產生的免疫反應。</span></div> <div class="ace-line ace-line old-record-id-doxcnW4AIUKYakY4acjI3E1yOH5" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="image-uploaded gallery old-record-id-doxcnsCOwMGMOKIsA0iL7R5vAZg" data-type="image" 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old-record-id-doxcnqkWKO6kU2o62kXh7HwSQoc" style="text-align: justify;"><span class="p">&ldquo;然而，貼片技術有可能在我們的武器庫中提供一種新的 - 更有效的 - 武器，而此時新變種正在迅速變異。</span></div> <div class="ace-line ace-line old-record-id-doxcn0sYUAuaKwIWgohuqVD24Qf" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnEgouck6YaUAYiMPneQ93Yc" style="text-align: justify;"><span class="p">&ldquo;這些貼劑不僅對新出現(xiàn)的變異更有效，而且比針頭疫苗更容易管理。</span></div> <div class="ace-line ace-line old-record-id-doxcnwQmUiyka4MkAGmCBrQVNQf" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnyWG8k6QsAa6A2mA9BpQmRf" style="text-align: justify;"><span class="p">&ldquo;但是，重要的是要強調，現(xiàn)有疫苗仍然是對抗這種病毒引起的嚴重疾病的有效方法，現(xiàn)在不是放松警惕的時候。</span></div> <div class="ace-line ace-line old-record-id-doxcnUA48OKqAMu8y2hfWvbYjJY" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcna0wOcokI4Aqmo5Rs1gZVbf" style="text-align: justify;"><span class="p">Vaxxas首席執(zhí)行官David Hoey表示，這進一步證明了該技術平臺在幫助各國更好地應對當前和未來大流行等全球突發(fā)衛(wèi)生事件方面可能具有改變游戲規(guī)則的潛力。</span></div> <div class="ace-line ace-line old-record-id-doxcnKkwESEcOscMYiD1txaXQos" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnesUOKuK80YmeSv6DeB3yBl" style="text-align: justify;"><span class="p">&ldquo;我們正在繼續(xù)擴大我們的制造能力，并加速產品開發(fā)，為大規(guī)模臨床試驗做準備，&rdquo;他說。</span></div> <div class="ace-line ace-line old-record-id-doxcn2gia8SuQEEUO4yuCSL8Iif" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnsUaO8UyKy4SOCizBuWl8sd" style="text-align: justify;"><span class="p">&ldquo;這包括在布里斯班建造我們的第一個生產設施，以支持我們的HD-MAP候選疫苗向商業(yè)化過渡，包括Hexapro COVID-19貼片。</span></div> <div class="ace-line" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcn0mWOiWm6w0gYEZKUWnnufc" style="text-align: justify;"><span class="p">該研究已發(fā)表在<em>《疫苗》上</em>。</span></div> <div class="ace-line ace-line old-record-id-doxcnGmgyskMQGAuWyoBo2sgdhc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnukyyKQmOKY0ckTaSLKtaYg" style="text-align: justify;"><span class="p">該研究由David Muller博士獲得的Advance Queensland Industry Research Fellowship資助。</span></div> <div class="ace-line ace-line old-record-id-doxcngMEo4E48IIi6oslxCx5XPm" style="text-align: justify;">&nbsp;</div> </div>